Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration
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چکیده
منابع مشابه
Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.
Amyloid-beta (Abeta) overproduction and dendrite arbor atrophy are hallmarks of Alzheimer's disease. The RhoA GTPase (Rho) signals through Rho kinase (ROCK) to control cytoskeletal dynamics and regulate neuron structure. Hyperactive Rho signaling destabilizes neurons leading to dendritic regression that can be rescued by genetic or pharmacological reduction of ROCK signaling. To understand what...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2010
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2010-091114